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Lucentis, Avastin, Eylea, Jetrea, Triesence, Ozurdex, Iluvien

Lucentis®

Lucentis, also known as ranibizumab injection, is a medication that was initially used to treat the wet form of age-related macular degeneration, also known as AMD or ARMD in 2006.  Age-related macular degeneration affects the macula, the part of the eye that provides sharp, central vision. Now Lucentis is also used for swelling in the macula, or macular edema, due to a vein occlusion or diabetes. Lucentis slows the development of vascular endothelial growth factor, or VEGF, a protein that causes abnormal blood vessels to grow and leak, damaging the macula. By slowing the development of VEGF, Lucentis aids in the prevention and reversal of vision loss experienced by patients with macular edema. Lucentis was designed specifically for use in the eye.

There are known side-effects in the use of Lucentis which include retinal detachment, increased intraocular pressure, intraocular inflammation, and infection.


Avastin®

Avastin, also known as bevacizumab, is a medication that is also used to swelling in the macula due to wet age-related macular degeneration, vein occlusion, or diabetes. The macula is the part of the eye that provides sharp, central vision. Avastin works by blocking the body from producing vascular endothelial growth factor, or VEGF, a protein that causes abnormal blood vessels to grow, damaging the macula. Avastin has been shown to improve vision for a variety of conditions.

Originally developed to treat metastatic colorectal cancer, Avastin is FDA-approved for that purpose. Studies have shown that Avastin can effectively be used to treat AMD, resulting in increased vision.  Ophthalmologists have been offering Avastin to their patients. Avastin is administered in a series of injections into the vitreous portion of the eye.


Eylea®

 
Eylea injection, also known as aflibercept, is a medication that was first used to treat the wet form of age-related macular degeneration, also known as AMD or ARMD. Age-related macular degeneration affects the macula, the part of the eye that provides sharp, central vision.  It is now used for swelling in the macula, or macular edema, due to vein occlusion or diabetes.

Eylea also slows the development of vascular endothelial growth factor, or VEGF, a protein that causes abnormal blood vessels to grow and leak, damaging the macula. By slowing the development of VEGF, Eylea aids in the prevention and reversal of vision loss experienced by those patients with macular degeneration.

Approved by the Food and Drug Administration in 2011, Eylea was evaluated in two clinical trials with over 2,000 patients. There are known side-effects in the use of Eylea which include retinal detachment, increased intraocular pressure, intraocular inflammation, and infection.


Jetrea®

Jetrea, also known as oriciplasmin, is a medication used for treatment of vitreomacular traction and macular holes. A macular hole is a hole in the center of the macula, the part of the eye that provides sharp, central vision. Vitreomacular traction is a condition where the vitreous gel has not completely separated from the retina resulting in pull on the retina. Jetrea is a shortened form of plasmin, a proteolytic enzyme that induces liquefaction of the vitreous, the gel like substance that fills the inside of the eye. This allows the vitreous to separate from the retina which aids in closure of the macular hole or, in the case of vitreomacular traction, releases the pull on the eye. Jetrea is an intravitreal injection that can be given in the office.


Triesence®

Triessence, also know as triamcinolone acetonide, is a steroid medication designed for use in the eye. Steroids are used throughout medicine and also extensively in ophthalmology. Triessence is used to treat swelling of the macula, or macular edema, from conditions such as diabetes, vein occlusions, and age-related macular degeneration. The macula is the part of the eye that provides sharp, central vision. Triessence is also used to treat inflammation of the eye or uveits.


Ozurdex®

Ozurdex, also known as the dexamethasone intravitreal implant, is a steroid implant designed for use in the eye. Steroids are used throughout medicine and also extensively in ophthalmology. Ozurdex is used to treat swelling of the macula, or macular edema, from conditions such as diabetes and vein occlusions. The macula is the part of the eye that provides sharp, central vision. Ozurdex is also used to treat inflammation of the eye or uveitis. The Ozurdex implant can be injected into the eye in the office.


Iluvien®

Iluvien, also know as the fluocinolone acetonide intravitreal implant, is a steroid implant designed for use in the eye. Steroids are used throughout medicine and also extensively in ophthalmology. Iluvien is used to treat swelling of the macula, or macular edema, from diabetes. The macula is the part of the eye that provides sharp, central vision. The Iluvien implant can be injected into the eye in the office.