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See the video below to hear about the first retinal chip implant performed locally by a Mid Atlantic Retina surgeon.

Research

The specialists of Mid Atlantic Retina continue to be in the forefront with their research efforts and in the development of major innovations in retina care. Mid Atlantic Retina participates in several clinical trials investigating new forms of treatment for macular degeneration, diabetic retinopathy, and a variety of other retinal conditions.

Non-exudative ("Dry") Age-related Macular Degeneration (AMD) Studies

FCFD4514S for Geographic Atrophy A Phase Ib/II, Multicenter, Randomized, Single-Masked, Sham Injection-Controlled Study of Safety, Tolerability, and Evidence of Activity of FCFD4514S Intravitreal Injections Administered Monthly or Every Other Month to Patients With Geographic Atrophy
CNTO 2476 Stem Cell Study for Geographic Atrophy Phase 1/2a, Multicenter, Randomized, Dose Escalation, Fellow-Eye Controlled Study Evaluating the Safety and Clinical Response of a Single, Subretinal Administration of Human Umbilical Tissue-Derived Cells (CNTO 2476) in Subjects With Visual Acuity Impairment Associated With the Geographic Atrophy

Neovascular (" Wet ") Age-related Macular Degeneration (AMD) Studies

MD7110852 Sponsored by Glaxo Smith Kline
A Phase 2b Dose-Ranging Study of Pazopanib Eye Drops Versus Ranibizumab Intravitreal Injections for the Treatment of Neovascular Age-Related Macular Degeneration
E10030 for Neovascular Age-related Macular Degeneration Sponsored by Ophthotech Corporation
A Phase 2, Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Injections of E10030 (Anti-PDGF Pegylated Aptamer) Given in Combination With Lucentis in Subjects With Neovascular Age-Related Macular Degeneration
C-09-067 (RACE) Sponsored by Alcon Research, Ltd.
Controlled, Double-Masked, Randomized, Multicenter Study to Evaluate AL-78898A as a Treatment of Exudative AMD
HARBOR Sponsored by Genentech
A Study of Ranibizumab Administered Monthly or on an As-Needed Basis in Patients With Subfoveal Neovascular Age-related Macular Degeneration.
AREDSII Sponsored by NEI
A Multi-Center, Randomized Trial of Lutein, Zeaxanthin and Omega-3 Long-Chain Polyunsaturated Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-related Macular Degeneration.
CABERNET Sponsored by Neo Vista
A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration.
CATT Sponsored by NEI
Comparison of Age-Related Macular Degeneration Treatments Trials: Evaluating the Relative Efficacy and Safety of Treatment of Wet Age-related Macular Degeneration with Lucentis or Avastin.
HORIZON Sponsored by Genentech
An Extension Study to Evaluate the Safety and Tolerability of Lucentis for Wet Age-related Macular Degeneration or Macular Edema Due to Retinal Vein Occlusion.
RADICAL Sponsored by QLT, Inc.
A Study Comparing Combination Therapy with Reduced Fluence Visudyne (Photodynamic Therapy)-Lucentis-Dexamethasone Versus Lucentis Alone for Wet Age-related Macular Degeneration.
VIEW Sponsored by Regeneron
A Study of the Efficacy and Safety of Intravitreal VEGF Trap-Eye in Subjects With Wet Age-related Macular Degeneration

Uveitis Studies

C-10-034 sponsored by Alcon Research
A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis
Allergan Study Sponsored by Allergan
A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate Uveitis.

Diabetic Retinopathy Studies

ACCORD Sponsored by NHLBI and NEI
Examining the effect of various treatments on cardiovascular disease in people with diabetes.
Alimera Sponsored by Alimera Sciences
Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema.
RISE Sponsored by Genentech
A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema With Center Involvement Secondary to Diabetes Mellitus.

Central Retinal Vein Occlusion Studies

VEGF Trap-Eye for CRVO Sponsored by Regeneron
A Study of the Efficacy, Safety, and Tolerability of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor Trap-Eye in Subjects With Macular Edema Due to Central Retinal Vein Occlusion.
CRUISE Sponsored by Genentech
A Study of the Efficacy and Safety of Lucentis Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion.

Branch Retinal Vein Occlusion Study

BRAVO Sponsored by Genentech
A Study of the Efficacy and Safety of Lucentis Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion.

Retinitis Pigmentosa Study

Argus™ II Retinal Stimulation System Feasibility Protocol Sponsored by Second Sight Medical Products
Evaluating the Safety and Utility of the Argus II Retinal Stimulation System in Providing Visual Function to Blind Subjects with Severe Retinitis Pigmentosa.

What Are Clinical Trials?

Clinical trials are research studies in people to answer specific health questions. Some research studies use participants with a particular illness or condition while others need healthy volunteers.

There are five types of clinical trials: treatment, prevention, diagnostic, screening, and quality of life. Treatment trials test new treatments and combinations of these treatments. Prevention trials look for ways to prevent disease from occurring or returning. Diagnostic trials seek better tests or procedures to diagnose a disease or condition. Screening trials test the best ways to detect a disease or condition. Quality of life trials study ways to improve quality of life in people with chronic illness.

Clinical trials are conducted in four phases:

Phase 1 studies examine a new drug or treatment for the first time in people (20-80), looking at safety, proper dose, and side effects.
Phase 2 studies examine the effectiveness and safety of a new drug or treatment in people (100-300) with a specific disease or condition.
Phase 3 clinical trials, which include 1,000-3,000 people, look at the effectiveness and safety of a new drug or treatment compared to the current standard treatment or to a placebo. Subjects are randomly assigned to receive the new drug/treatment or to the standard/placebo, similar to flipping a coin.
Phase 4 clinical trials collect more information on a drug or treatment after its approval in the United States by the Food and Drug Administration, including the best way to use it and its risks and benefits.

Participation in ALL clinical trials is voluntary, and you can leave a clinical trial at any time. Most clinical trials are sponsored by the federally-funded National Institutes of Health (NIH) or pharmaceutical and biotechnology companies. The NIH’s Clinicaltrials.gov Web site lists thousands of clinical trials.

For additional information, contact our research department directly at research@midatlanticretina.com or 215-928-3092